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Updated: Jul 17, 2026
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Isolation of Mouse Endometrial Epithelial and Stromal Cells for In Vitro Decidualization
Published on: March 2, 2017
Relaxin and decidualization in mice: a reappraisal
C A Finn1, M D Pope, S R Milligan
1Department of Veterinary Preclinical Sciences, University of Liverpool, United Kingdom. finn@liv.ac.uk
Biology of Reproduction
|December 1, 1996
Summary
This study investigated relaxin
Area of Science:
- Reproductive biology
- Endocrinology
Background:
- Decidualization is a critical process in early pregnancy.
- The specific physiological stimulus triggering decidualization remains unclear.
Purpose of the Study:
- To investigate the potential role of relaxin as a deciduogenic stimulus.
- To verify a previous report suggesting relaxin induces decidualization.
Main Methods:
- Mice were treated with estradiol valerate and medroxyprogesterone acetate.
- Subcutaneous and intrauterine relaxin administration was tested.
- Intraluminal arachis oil was used as a positive control.
- Decidualization was assessed by uterine weight and biochemical markers.
Main Results:
- Neither subcutaneous nor intrauterine relaxin induced decidualization in intact or ovariectomized mice.
- Arachis oil successfully induced decidualization in ovariectomized mice.
- Hormonal priming regimens did not confer sensitivity to relaxin.
Conclusions:
- This study found no evidence supporting relaxin's role in inducing decidualization.
- Relaxin is unlikely to be a physiological deciduogenic stimulus in mice.
