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Related Experiment Videos

Nucleus accumbens lesion does not affect schedule induced polydipsia

K H Balraj1, B Barathi, D P Thombre

  • 1Department of Physiology, JIPMER, Pondicherry.

Indian Journal of Physiology and Pharmacology
|July 1, 1996
PubMed
Summary

Lesions in the nucleus accumbens reduce drinking in rats during free feeding but do not affect schedule-induced polydipsia (SIP). This suggests the nucleus accumbens is not critical for SIP acquisition or maintenance.

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Area of Science:

  • Neuroscience
  • Behavioral Neuroscience
  • Animal Models

Background:

  • The nucleus accumbens plays a role in motivated behaviors, including drinking.
  • Rats with nucleus accumbens lesions exhibit reduced drinking under ad libitum feeding conditions.

Purpose of the Study:

  • To investigate the role of the nucleus accumbens in schedule-induced polydipsia (SIP).
  • To determine if nucleus accumbens lesions affect the acquisition or maintenance of SIP.

Main Methods:

  • Rats underwent lesions of the nucleus accumbens.
  • Rats were food-deprived to 70% of free-feeding body weight.
  • Schedule-induced polydipsia was assessed by delivering food pellets on a fixed-time 1-min schedule.

Main Results:

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  • Nucleus accumbens lesions did not delay the acquisition of SIP.
  • Nucleus accumbens lesions did not decrease the maintenance of SIP.
  • Rats with nucleus accumbens lesions remained hypodipsic under free-feeding conditions.

Conclusions:

  • The nucleus accumbens is not essential for the acquisition or maintenance of schedule-induced polydipsia.
  • These findings differentiate the neural mechanisms underlying normal drinking and SIP.