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Late reversibility of chronic ifosfamide-associated nephrotoxicity in a child
M S Ashraf1, R Skinner, M W English
1Sir James Spence Institute of Child Health, Royal Victoria Infirmary, Newcastle upon Tyne, England.
Insights
This study reports the first documented case of complete recovery from chronic ifosfamide-induced kidney damage in a child. It highlights the potential for sustained renal function restoration after chemotherapy-related nephrotoxicity.
Area of Science:
- Pediatric Oncology
- Nephrology
- Chemotherapy-induced Toxicity
Background:
- Acute ifosfamide-induced nephrotoxicity is reversible, but data on chronic renal toxicity outcomes is limited.
- Full recovery from established chronic kidney damage due to ifosfamide has not been previously reported.
Abstract:
Although reversibility of acute ifosfamide-induced nephrotoxicity is well documented, there is a paucity of data concerning the long-term outcome of chronic renal toxicity, and full recovery from established damage has not been reported. A 4-year-old boy presented with hypophosphatemic rickets 9 months after completion of combination chemotherapy (including ifosfamide) for prostatic rhabdomyosarcoma. Further investigation confirmed glomerular and generalised tubular dysfunction with a Fanconi syndrome. However, serial investigation over the next 4 years revealed complete and sustained recovery of this chronic nephrotoxicity.