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Nonresponse to hepatitis B vaccines and the kinetics of anti-HBs production
1Academic Unit of Travel Medicine and Vaccines, Royal Free Hospital School of Medicine, London, United Kingdom.
Journal of Medical Virology
|December 1, 1996
Abstract:
No empirical data are available for the anti-HBs title required for protection against infection with the hepatitis B virus (HBV), but nonresponders to hepatitis B vaccines remain susceptible to infection. There may be an unexplained qualitative difference between hyporesponders and true nonresponders, but there is a clear association with HLA haplotypes. There is no evidence for silent infection with HBV in nonresponders.