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Related Experiment Videos

Varicella in Chimpanzees

J I Cohen1, T Moskal, M Shapiro

  • 1Molecular Virology Unit, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

Journal of Medical Virology
|December 1, 1996
PubMed
Summary
This summary is machine-generated.

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Two chimpanzees inoculated with varicella-zoster virus (VZV) developed a mild rash. This suggests chimpanzees may serve as a model for studying VZV virulence and attenuation.

Area of Science:

  • Virology
  • Immunology
  • Primate models

Background:

  • Varicella-zoster virus (VZV) causes chickenpox and shingles.
  • Animal models are crucial for understanding VZV pathogenesis and developing countermeasures.

Purpose of the Study:

  • To investigate the susceptibility of chimpanzees to VZV infection.
  • To evaluate chimpanzees as a potential model for VZV research.

Main Methods:

  • Subcutaneous inoculation of two chimpanzees with wild-type Oka strain VZV.
  • Detection of viral DNA in peripheral blood mononuclear cells and skin biopsies using polymerase chain reaction (PCR).
  • Clinical observation for rash development.

Main Results:

  • Viral DNA was detected in peripheral blood mononuclear cells of both chimpanzees post-inoculation.

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  • Both animals developed a mild, localized erythematous, papular rash.
  • VZV DNA was confirmed in a skin biopsy from one animal during the rash phase.

    • Conclusions:

    • Chimpanzees can be infected with VZV, exhibiting a mild form of varicella.
    • These findings support the potential utility of chimpanzees for molecular studies on VZV genes related to virulence and attenuation.