Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Fetal circulatory responses during maternal bleeding

H Yoshihara1, T Genda, S Nemoto

  • 1Department of Obstetrics and Gynecology, School of Medicine, Kitasato University, Japan.

Journal of Perinatal Medicine
|January 1, 1996
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Association between antinuclear antibodies and pregnancy prognosis in recurrent pregnancy loss patients.

Human reproduction (Oxford, England)·2024
Same author

Phosphorus recovery from the sludge generated from a continuous bipolar mode electrocoagulation (CBME) system.

Water science and technology : a journal of the International Association on Water Pollution Research·2019
Same author

Chapter Seven - When Phosphorylation Encounters Ubiquitination: A Balanced Perspective on IGF-1R Signaling.

Progress in molecular biology and translational science·2016
Same author

Antileukemia multifunctionality of CD4(+) T cells genetically engineered by HLA class I-restricted and WT1-specific T-cell receptor gene transfer.

Leukemia·2015
Same author

The real impact of telaprevir dosage on the antiviral and side effects of telaprevir, pegylated interferon and ribavirin therapy for chronic hepatitis C patients with HCV genotype 1.

Journal of viral hepatitis·2014
Same author

Risk factors for hepatocellular carcinoma in hepatitis C patients with normal alanine aminotransferase treated with pegylated interferon and ribavirin.

Journal of viral hepatitis·2014

Maternal hemorrhage significantly impacts fetal circulation, decreasing oxygen and pH while increasing carbon dioxide and blood pressure. Fetal arginine vasopressin levels rise, and some parameters do not recover post-resuscitation.

Area of Science:

  • Perinatal physiology
  • Maternal-fetal medicine
  • Cardiovascular research

Background:

  • Maternal hemorrhage poses risks to fetal well-being.
  • Understanding fetal circulatory adaptation is crucial for managing obstetric emergencies.

Purpose of the Study:

  • To investigate fetal circulatory and hormonal responses to acute maternal hemorrhage.
  • To assess the recovery of fetal parameters after maternal blood volume restoration.

Main Methods:

  • Utilized a pregnant goat model (n=5) with fetuses at ~132 days gestation.
  • Administered controlled maternal hemorrhage (700 ml over 2 hours) followed by reinfusion.
  • Monitored maternal arterial pressure, fetal arterial blood gases (pO2, PCO2, pH), fetal arterial pressure (FAP), fetal heart rate (FHR), and fetal arginine vasopressin (AVP) levels.

Related Experiment Videos

Main Results:

  • Maternal hypotension led to decreased fetal pO2 and pH, and increased fetal PCO2.
  • Fetal arterial pressure increased, and fetal heart rate decreased during hemorrhage.
  • Fetal arginine vasopressin levels significantly elevated, correlating positively with FAP and negatively with FHR.
  • Post-reinfusion, fetal pO2 recovered, but pH, PCO2, and AVP did not return to baseline.

Conclusions:

  • Acute maternal hemorrhage induces significant fetal circulatory and metabolic distress.
  • Elevated fetal arginine vasopressin suggests a role in fetal cardiovascular adaptation during hypovolemia.
  • Incomplete recovery of fetal acid-base balance and hormonal levels indicates potential long-term consequences despite fluid resuscitation.