Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Malaric placentas. A quantitative study and clinico-pathological correlations

O Leopardi1, W Naughten, L Salvia

  • 1Department of Pathology, Ospedale Maggiore, Lodi, Italy.

Pathology, Research and Practice
|September 1, 1996
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Outcomes of immune-checkpoint inhibitor rechallenge in metastatic clear-cell renal cell carcinoma: results from a global real-world evidence study.

ESMO open·2026
Same author

Response to the Union's statement on ongoing conflicts and impact on health services.

IJTLD open·2026
Same author

Search for Axion Dark Matter from 1.1 to 1.3 GHz with ADMX.

Physical review letters·2025
Same author

Natural history of nonfunctioning pituitary microadenomas: a systematic review and individual participant data meta-analysis.

European journal of endocrinology·2025
Same author

ADMX Axion Dark Matter Bounds around 3.3  μeV with Dine-Fischler-Srednicki-Zhitnitsky Discovery Ability.

Physical review letters·2025
Same author

Cascade of care for TB infection in persons newly diagnosed with HIV in Italy.

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease·2024
Same journal

Autophagy modulation in ulcerative colitis with traditional Chinese medicine: A review.

Pathology, research and practice·2026
Same journal

Ras signalling in infectious disease pathology: Mechanisms, tissue damage, and clinical implications.

Pathology, research and practice·2026
Same journal

CBFβ-SMMHC in inv(16) AML: Fusion biology, RUNX1 dysregulation, and therapeutic targeting of a leukemogenic protein-protein interaction.

Pathology, research and practice·2026
Same journal

Multifactorial pathophysiology of varicocele: Integrating hemodynamic, oxidative, and endocrine mechanisms.

Pathology, research and practice·2026
Same journal

Comparative pathophysiology and pathology of transient ischemic attack, ischemic stroke, and reperfusion injury: Mechanistic and therapeutic perspectives.

Pathology, research and practice·2026
Same journal

Taraxerol targets the HIF1A-NEK6 axis to block TDE-mediated M2 macrophage polarization and inhibits NSCLC progression.

Pathology, research and practice·2026
See all related articles

Low birthweight in malaria is linked to placental inflammation, not parasite load. Placental inflammation, especially with lymphocytes, correlates with lower birthweight, suggesting adaptive changes.

Area of Science:

  • Obstetrics and Gynecology
  • Infectious Diseases
  • Pathology

Background:

  • Malaria infection during pregnancy is a significant global health concern.
  • Placental changes associated with malaria can impact fetal development and birth outcomes.
  • Understanding the specific placental factors contributing to low birthweight is crucial for intervention.

Purpose of the Study:

  • To investigate the histological and morphometric characteristics of placentae from malaria-infected and non-infected pregnancies.
  • To determine the relationship between placental malaria, inflammation, and birthweight.
  • To elucidate the role of fibrin, intervillous space, and villi volumes in malaria-associated low birthweight.

Main Methods:

  • Histological and morphometric analysis of 372 placentae.

Related Experiment Videos

  • Point-counting and linear intercept methods for volume and ratio determination.
  • Semiquantitative grading of parasitemia and inflammatory reactions.

    • Main Results:

    • Active malaria (AM), past malaria (PM), and non-malarial (NM) placentae showed no significant weight difference.
    • Newborns from AM pregnancies had significantly lower birthweights than those from PM and NM.
    • Placental inflammation, particularly lymphocyte presence in the intervillous space (IVS), correlated with decreased birthweight.
    • Increased fibrin volume was observed in AM and PM placentae; IVS and villi volumes did not differ significantly.
    • Increased syncytium/capillaries ratio was noted in AM placentae.

    Conclusions:

    • Low birthweight in malaria is primarily associated with intervillous space inflammation, not fibrin deposits or parasite load.
    • Non-leukotactic lymphokines may play a role in the inflammatory process.
    • Observed placental morphology suggests a less mature placenta, potentially an adaptive response to malaria.