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Related Experiment Videos

Ethanol binding to a model carbohydrate, glycogen

S Channareddy1, S S Jose, N Janes

  • 1Department of Pathology, Anatomy, and Cell Biology, Medical College of Thomas Jefferson University, Philadelphia, PA 19107, USA.

Biochemical Pharmacology
|December 24, 1996
PubMed
Summary

This study found that carbohydrates, like glycogen, do not strongly bind to ethanol. Ethanol

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Area of Science:

  • Biochemistry
  • Molecular Biology
  • Carbohydrate Chemistry

Background:

  • Glycoconjugates are hypothesized to be targets of ethanol.
  • Ethanol affects glycogen content in muscle, liver, and brain.

Purpose of the Study:

  • To determine if carbohydrates bind ethanol.
  • To investigate ethanol's affinity for glycogen.

Main Methods:

  • Measured ethanol and small molecule binding to glycogen.
  • Assessed binding affinity and concentration dependence.

Main Results:

  • Ethanol binding to glycogen was weak and concentration-independent.
  • Glycerol and other polar molecules bound glycogen more strongly than ethanol.
  • Water binding to glycogen exceeded all solute binding.

Conclusions:

  • Carbohydrates lack strong affinity or specificity for ethanol.
  • Glycogen's hydration structure accommodates polar solutes but excludes ethanol.

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