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Published on: September 24, 2010
Lymphocytes produce specific alkaline phosphatase after in vitro stimulation or after in vivo infection with HIV-1
1Department of Laboratory Medicine, Albert Einstein College of Medicine, The Bronx, New York, USA.
Abstract:
A unique alkaline phosphatase isoform found in the serum of HIV-1 infected patients is thought to originate from CD4 lymphocytes. Destruction of activated CD4 lymphocytes after HIV-1 infection is probably responsible for the appearance of this isoform in circulation. This band-10 alkaline phosphatase isoform is thus useful as an early marker for detecting AIDS in children born to HIV-1 infected mothers.
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