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Ritanserin blocks DOI-altered embryonic motility and posthatch learning in the developing chicken

G Bollweg1, S Sparber

  • 1Department of Pharmacology, University of Minnesota, Minneapolis 55455, USA.

Pharmacology, Biochemistry, and Behavior
|November 1, 1996
PubMed
Summary

Cocaine exposure during embryonic development affects chicken embryo behavior. The drug ritanserin (RIT) blocks some of these effects, suggesting RIT-like drugs may counteract cocaine's developmental toxicity.

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Area of Science:

  • Neuroscience
  • Developmental Biology
  • Pharmacology

Background:

  • Cocaine exposure in developing chicken embryos alters motility, hatchability, and learning.
  • Serotonin 2 (5-HT2) receptor antagonism with ritanserin (RIT) mitigates some cocaine-induced effects, suggesting 5-HT2 receptor involvement.

Purpose of the Study:

  • To investigate the behavioral effects of selective 5-HT2 receptor stimulation and blockade during embryonic development.
  • To compare the developmental effects of a 5-HT2 agonist with those of cocaine.

Main Methods:

  • Chicken embryos at 15 days of development were injected with the 5-HT2 agonist dimethoxyiodophenylaminopropane (DOI).
  • Ritanserin (RIT) was administered 1 hour after DOI to assess blockade effects.
  • Motility was recorded at 2.5 and 24 hours post-DOI; hatchability was monitored.

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  • Posthatch detour learning was assessed in treated subjects.

    • Main Results:

    • DOI (1.0 mg/kg) transiently suppressed motility at 2.5 hours, an effect blocked by both RIT doses (0.3 and 0.9 mg/kg).
    • No significant effects on hatchability were observed with any treatment.
    • DOI exposure enhanced detour learning acquisition (reduced latency), a cocaine-like effect, which was also blocked by RIT.

    Conclusions:

    • Selective 5-HT2 receptor stimulation with DOI during late embryonic development produces some cocaine-like behavioral effects.
    • Ritanserin effectively blocks these DOI-induced behavioral changes, including altered motility and enhanced learning.
    • These findings suggest a potential therapeutic role for ritanserin-like drugs in mitigating cocaine's developmental toxicity.