Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Extramedullary acute promyelocytic leukemia

P H Wiernik1, R De Bellis, P Muxi

  • 1Albert Einstein Cancer Center, Bronx, New York 10467, USA.

Cancer
|December 15, 1996
PubMed
Summary

Extramedullary acute promyelocytic leukemia (APL) is rare. While data suggest it may occur more frequently after all-trans retinoic acid (ATRA) treatment, it can also develop after chemotherapy or before initial treatment.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Overall survival by clinical risk category for high dose interleukin-2 (HD IL-2) treated patients with metastatic renal cell cancer (mRCC): data from the PROCLAIM<sup>SM</sup> registry.

Journal for immunotherapy of cancer·2019
Same author

A phase I study of cabozantinib (XL184) in patients with renal cell cancer.

Annals of oncology : official journal of the European Society for Medical Oncology·2014
Same author

Characterization of bone metastases in patients with renal cell cancer.

BJU international·2004
Same author

Accelerated and blastic phase of chronic myeloid leukemia.

Current treatment options in oncology·2002
Same author

Phase I study of recombinant human CD40 ligand in cancer patients.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology·2001
Same author

Angiogenesis and melanoma.

Current oncology reports·2001

Area of Science:

  • Hematology
  • Oncology
  • Clinical Medicine

Background:

  • Extramedullary acute promyelocytic leukemia (APL) is an uncommon manifestation.
  • The incidence of extramedullary APL following all-trans retinoic acid (ATRA) therapy is debated.
  • This study reviews cases and literature to investigate extramedullary APL occurrence.

Observation:

  • Two cases of extramedullary APL relapse are presented: one in a child treated with ATRA, another in an adult treated with chemotherapy.
  • A literature review identified 26 patients with extramedullary APL.
  • Common sites included skin, central nervous system, mediastinum, and gingiva.

Findings:

  • Extramedullary leukemia developed in 19 patients after ATRA (6), chemotherapy (12), or both (1).
  • Seven patients developed extramedullary APL before any leukemia treatment.
  • While not definitive, findings suggest a potential increase in extramedullary APL after ATRA compared to chemotherapy.

Implications:

  • The findings suggest a possible association between ATRA therapy and extramedullary APL, warranting further investigation.
  • Extramedullary APL is a recognized complication that can occur irrespective of treatment modality.
  • Understanding these patterns is crucial for monitoring and managing APL patients, particularly those receiving ATRA.

Related Experiment Videos