Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Prolactin and systemic lupus erythematosus

R W McMurray1

  • 1Department of Medicine, University of Mississippi Medical Center, Jackson 39216, USA.

Annales De Medecine Interne
|January 1, 1996
PubMed
Summary

Elevated prolactin levels may worsen systemic lupus erythematosus (SLE) and its associated autoimmunity. Lowering prolactin showed potential improvement in SLE patients, suggesting a new therapeutic target.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effects of chronic exposure to DDT and TCDD on disease activity in murine systemic lupus erythematosus.

Lupus·2009
Same author

Hepatitis C virus and systemic lupus erythematosus.

Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases·2008
Same author

Osteoarthritis of the sternoclavicular joint.

Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases·2008
Same author

Estrogen and progesterone modulate monocyte cell cycle progression and apoptosis.

American journal of reproductive immunology (New York, N.Y. : 1989)·2003
Same author

Sex hormones in the pathogenesis of systemic lupus erythematosus.

Frontiers in bioscience : a journal and virtual library·2001
Same author

Prolactin in murine systemic lupus erythematosus.

Lupus·2001

Area of Science:

  • Endocrinology
  • Immunology
  • Rheumatology

Background:

  • Prolactin is an immunomodulatory pituitary peptide hormone.
  • Increased prolactin concentrations are linked to accelerated autoimmunity in mouse models of SLE.
  • Hyperprolactinemia is observed in some SLE patients and correlates with disease activity.

Purpose of the Study:

  • To investigate the role of prolactin in systemic lupus erythematosus (SLE).
  • To explore the potential of prolactin suppression as a therapeutic strategy for SLE.

Main Methods:

  • Review of existing cross-sectional and longitudinal studies on prolactin and SLE.
  • Analysis of preliminary studies involving bromocriptine administration to suppress prolactin levels.

Main Results:

  • Elevated serum prolactin is associated with lupus disease activity.
  • Bromocriptine administration to suppress prolactin levels showed improvement in SLE in a preliminary study.
  • Prolactin appears to be immunostimulatory in SLE patients.

Conclusions:

  • Prolactin may play a significant role in the immunopathogenesis of SLE.
  • Understanding prolactin's interactions with other hormones could lead to novel SLE therapies.
  • Targeting prolactin offers a potential avenue for managing this autoimmune disease.

Related Experiment Videos