Related Experiment Video
Updated: Aug 10, 2026

The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice
Published on: November 1, 2015
Prolactin and systemic lupus erythematosus
1Department of Medicine, University of Mississippi Medical Center, Jackson 39216, USA.
Abstract:
Prolactin in a pituitary peptide hormone which is immunomodulatory. Increased serum prolactin concentrations accelerate autoimmunity in the NZB x NZW F1 mouse model of SLE. Some patients with SLE are hyperprolactinemic and, in cross-sectional and longitudinal studies, serum prolactin has been associated with or correlated to lupus disease activity. Suppression of physiologic levels of prolactin by bromocriptine administration was associated with improvement in SLE in a preliminary study. While specific mechanisms remain to be elucidated, prolactin appears to be immunostimulatory in patients with SLE. A better understanding of its role and its interactions with other immunoregulatory hormones in SLE may lead to novel therapies for the suppression of this hormonally sensitive autoimmune disease.
More Related Videos
09:43Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
Published on: June 8, 2022
10:21Primary Sjogren's Syndrome Associated with Lung Adenocarcinoma: Probing the Potential Common Pathogenic Mechanisms and Experimental Verification
Published on: September 20, 2024
Related Concept Videos
Nephrotic Syndrome III : Nursing Management
Cushing Syndrome II: Pathophysiology