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[Role of type II secreted phospholipase A2 in inflammatory processes]
1URA CNRS 1283, Faculté de Médecine Saint-Antoine, Paris, France.
Comptes Rendus Des Seances De La Societe De Biologie Et De Ses Filiales
|January 1, 1996
Abstract:
Secreted phospholipase A2 has been detected in numerous inflammatory and infectious diseases. Since the cloning of the type II sPLA2 in 1989 from rheumatoid arthritis synovial fluid, a direct or indirect participation of type II sPLA2 in the production of lipid mediators has been purposed. This paper reviews the different studies from the literature alleging that type II sPLA2 participates to inflammatory processes and lipid mediators synthesis.