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Intestinal secretory defects and dwarfism in mice lacking cGMP-dependent protein kinase II
A Pfeifer1, A Aszódi, U Seidler
1Institut f-ur Pharmakologie und Toxikologie, Technische Universität München, Biedersteiner Strasse 29, D-80802 M-unchen, Germany. pfeifer@ipt.med.tu-muenchen.de
Science (New York, N.Y.)
|December 20, 1996
Abstract:
Cyclic guanosine 3',5'-monophosphate (cGMP)-dependent protein kinases (cGKs) mediate cellular signaling induced by nitric oxide and cGMP. Mice deficient in the type II cGK were resistant to Escherichia coli STa, an enterotoxin that stimulates cGMP accumulation and intestinal fluid secretion. The cGKII-deficient mice also developed dwarfism that was caused by a severe defect in endochondral ossification at the growth plates. These results indicate that cGKII plays a central role in diverse physiological processes.