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[Repeated administration of protamine attenuates protamine-induced systemic hypotension]
Masui. the Japanese Journal of Anesthesiology
|November 1, 1996
Summary
Repeated administration of protamine reduces protamine-induced hypotension in rats. This suggests protamine releases nitric oxide, causing vasodilation and mitigating blood pressure drops.
Area of Science:
- Pharmacology
- Cardiovascular Physiology
Context:
- Protamine administration can cause systemic hypotension.
- Nitric oxide (NO) mediates vasodilation and influences blood pressure regulation.
Purpose:
- To investigate whether repeated protamine administration attenuates protamine-induced systemic hypotension in a rat model.
- To explore the potential role of nitric oxide in this phenomenon.
Summary:
- Rats received either a single bolus injection (S group) or repeated administration (continuous infusion followed by bolus) of protamine (10 mg.kg-1).
- The S group exhibited a significant decrease in mean arterial pressure post-protamine compared to the R group.
- The maximal rate of arterial pressure decrease was also significantly lower in the R group, indicating an attenuation of hypotension.
Impact:
- These findings demonstrate that repeated protamine administration attenuates protamine-induced hypotension.
- The results support the hypothesis that protamine-induced hypotension involves nitric oxide release mediated by endothelial cell receptors.