[Experimental study on CDDP, 5-FU concentrations of paraaortic and mesenteric lymph nodes after subphrenic infusion]

We examined about CDDP, 5-FU concentration of paraaortic and mesenteric lymph nodes in rats after subphrenic infusion. Rats were administrated 5-FU 1 ml (250 mg/kg) or CDDP 1 ml (2.5 mg/kg) via three routes, subphrenic, Douglas, and intravenously. Compared 5-FU concentration of lymph nodes between intravenous infusion group and intraperitoneal infusion group (subphrenic infusion group + Douglas infusion group) after high dose administration, the concentration of lymph nodes in the intraperitoneal group were about 2.5 times higher value maintained than that of the intravenous infusion group significantly. Also the same results were obtained even in the cases administrated regular dose CDDP. Compared subphrenic infusion group with Douglas infusion group for CDDP, 5-FU concentration of lymph nodes, there was no significant difference between 2 groups. However, there was a tendency that the CDDP, 5-FU concentration of lymph nodes of the subphrenic infusion group was higher value maintained than that of the Douglas infusion group. Therefore it is conceivable that the subphrenic infusion therapy may be expected for the clinical application in the future.