Related Experiment Video
Updated: Jul 26, 2026

Quantification of Atherosclerosis in Mice
Published on: June 12, 2019
[Atherosclerosis and clinical examination: epidemiology of stroke and ischemic heart disease]
Insights
Hypertension is a primary risk factor for stroke, while increasing total cholesterol (TCH) is linked to fewer cerebral hemorrhages. Japan
Area of Science:
- Cardiovascular epidemiology
- Atherosclerotic diseases
- Public health
Context:
- Stroke and ischemic heart disease (IHD) are major atherosclerotic diseases with distinct risk factors.
- Hypertension is identified as the principal risk factor for both cerebral hemorrhage and infarction.
- Total cholesterol (TCH) shows an inverse relationship with cerebral hemorrhage incidence.
Purpose:
- To analyze and compare risk factors for stroke and IHD.
- To examine trends in TCH levels and IHD incidence in Japan.
- To evaluate the impact of changing diagnostic criteria on IHD death statistics.
Summary:
- Hypertension is the leading risk factor for stroke, while elevated TCH is inversely associated with cerebral hemorrhage.
- Despite decreasing stroke incidence due to hypertension control, IHD is a growing concern in Japan as TCH levels rise.
- Revised death certificate forms (ICD-10) will improve IHD mortality data accuracy.
Impact:
- Findings necessitate a re-evaluation of preventive strategies for IHD in Japan.
- Understanding differing mechanisms between stroke and IHD is crucial for targeted interventions.
- Accurate IHD statistics are essential for effective public health policy and resource allocation.
Abstract:
We discussed the risk factors for stroke and ischemic heart disease (IHD) as a main atherosclerotic disease. We showed that hypertension was the most principal risk factor for both cerebral hemorrhage and cerebral infarction, and the increase of total cholesterol (TCH) was inversely related with the incidence of cerebral hemorrhage. Many of the cerebral infarctions occurred where a large number of the cerebral hemorrhages did. We indicated that the mechanism of occurrence was different between stroke and IHD. In Japan, TCH has been recognized as a risk factor for IHD as same as western countries, but there are not many IHD. The mean of TCH was lower before one or two decade. But, it has increased in the last decade, and recently is nearing the level of American people in the thirties and forties. Death statistics of IHD became more accurate in Japan by reason for revision of the death certificate form from ICD-9 to ICD-10. The recognition of IHD death statistics will be changed. Incidence of stroke has been decreasing because of the decrease of hypertension. However, we will have to reconsider a preventive measure of IHD.
More Related Videos
13:07Optical Coherence Tomography Based Biomechanical Fluid-Structure Interaction Analysis of Coronary Atherosclerosis Progression
Published on: January 15, 2022
09:36A Magnetic Resonance Imaging-based Computational Protocol for Analysis of Plaque Morphology and Hemodynamics in Patients with Carotid Artery Stenosis
Published on: August 12, 2025
Related Concept Videos
Ischemic Heart Disease: Overview
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and narrowing...
Atherosclerosis I: Introduction
Atherosclerosis II: Clinical Manifestations and Diagnostic Tests
Atherosclerosis III: Management
Atherosclerosis IV: Nursing Management
Aneurysm II: Clinical Manifestations and Diagnostic Studies