Brunfelsia hopeana I: Hippocratic screening and antiinflammatory evaluation

Hippocratic screening, in rats, of the whole root and extracts of Brunfelsia hopeana administered intraperitonially indicated that the whole root has CNS depressent activity and that the chloroform extract (F) which contains the basic or 'alkaloidal' fraction concentrates this activity. Extract (F) at an oral dose level of 100 mg/kg, was equally effective (w/w) as phenylbutazone in reducing carrageenin-induced pedal edema in rats.