Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Targeted Gene Disruption in the CNS to Study Learning and Behavior

Grant1

  • 1Centre for Genome Research and Centre for Neuroscience, University of Edinburgh, West Mains Road, Edinburgh, EH9-3JQ, United Kingdom

Methods (San Diego, Calif.)
|December 1, 1996
PubMed
Summary

Mice are now a powerful model for studying learning and memory, thanks to gene-targeting technology. Researchers can now link molecular changes to cognitive function in mice.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Isothermal Adsorption of Aflatoxin B(1) on HSCAS Clay.

Journal of agricultural and food chemistry·2001
Same author

Spectral function of composites from reflectivity measurements

Physical review letters·2000
Same author

Superconductivity. Currents without borders

Nature·2000
Same author

Removal of Solid Organic Films from Rotating Disks Using Emulsion Cleaners.

Journal of colloid and interface science·2000
Same author

High Oxidation State Organocobalt Complexes: Synthesis and Characterization of Dihydridodisilyl Cobalt(V) Species We thank the National Institutes of Health (Grant GM 28938) for financial support. C.P.L. thanks the Fonds der Chemischen Industrie, Germany, for a Kekulé fellowship. Allocation of computing time by the North Carolina Supercomputing Center is gratefully acknowledged.

Angewandte Chemie (International ed. in English)·2000
Same author

Reply

Letters in applied microbiology·2000

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Cognitive Science

Background:

  • The mouse was historically underutilized for learning and memory research.
  • Advances in gene-targeting technology enable precise control over protein expression in vivo.
  • Mice offer a unique platform for integrating molecular, physiological, and behavioral analyses.

Purpose of the Study:

  • To review methodologies for characterizing mouse models with synaptic and behavioral abnormalities.
  • To highlight the utility of mice in studying the molecular basis of learning and memory.
  • To discuss challenges in interpreting data from genetically modified mouse models.

Main Methods:

  • Gene-targeting technologies for protein manipulation.
  • Electrophysiological and biochemical analyses of neurons.

Related Experiment Videos

  • Behavioral assessments of cognitive function in mouse mutants.
  • Neuroanatomical and neurochemical profiling.

    • Main Results:

    • Mouse mutants exhibiting altered synaptic physiology, neuroanatomy, neurochemistry, and behavior have been developed.
    • These mutants allow for the correlation of specific molecular alterations with observed phenotypes.
    • The study provides a framework for integrating diverse methodologies to study cognitive function.

    Conclusions:

    • Mice are now a crucial model organism for investigating the biological underpinnings of learning and memory.
    • The integration of molecular, physiological, and behavioral techniques is essential for a comprehensive understanding.
    • Further research is needed to overcome interpretative challenges in complex mouse models.