Related Experiment Videos
Enteric neurons express Steel factor-lacZ transgene in the murine gastrointestinal tract
S Torihashi1, H Yoshida, S Nishikawa
1Department of Physiology and Cell Biology, University of Nevada, School of Medicine, Reno 89557, USA.
Brain Research
|November 4, 1996
Abstract:
The cells that express Steel factor (SLF) in the gastrointestinal (GI) tract were studied using SLF-lacZ transgenic mice. Expression, detected by beta-galactosidase histochemistry, was evident in cells between the circular and longitudinal muscle layers in the GI tract. Double staining with antibodies specific for the neural markers, PGP 9.5, MAP2 and c-Ret, showed that SLF-lacZ positive cells were enteric neurons. Enteroglia did not express SLF-lacZ. The distribution of expressing cells was complimentary to the expression of c-Kit in myenteric interstitial cells.