Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Leg ulcers in sickle cell disease

J R Eckman1

  • 1Division of Hematology-Oncology, Georgia N.I.H. Comprehensive Sickle Cell Center, Grady Memorial Hospital, Emory University School of Medicine, Atlanta, USA.

Hematology/Oncology Clinics of North America
|December 1, 1996
PubMed
Summary

Leg ulcers in sickle cell anemia and S/beta thalassemia patients cause disability. Conservative treatments heal most ulcers, but chronic cases remain challenging without clear clinical trial guidance.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Transfusion service knowledge and immunohaematological practices related to sickle cell disease and thalassemia.

Transfusion medicine (Oxford, England)·2019
Same author

The Mayo Clinic and the Canadians.

Canadian Medical Association journal·2010
Same author

Activation of vascular endothelial cell adhesion molecule expression by sickle blood cells.

Pediatric pathology & molecular medicine·2003
Same author

Reduction of pain episodes and prothrombotic activity in sickle cell disease by dietary n-3 fatty acids.

Thrombosis and haemostasis·2001
Same author

Thrombogenesis in sickle cell disease.

The Journal of laboratory and clinical medicine·2001
Same author

Techniques for blood administration in sickle cell patients.

Seminars in hematology·2001

Area of Science:

  • Hematology
  • Vascular Medicine
  • Wound Care

Background:

  • Leg ulcers are common in sickle cell anemia and S/beta-thalassemia.
  • These ulcers lead to significant physical, psychologic, and social challenges for patients.

Purpose of the Study:

  • To review the current understanding and management of leg ulcers in patients with hemoglobinopathies.
  • To highlight the challenges posed by chronic, recalcitrant leg ulcers in this population.

Main Methods:

  • Review of conservative treatment strategies including gentle debridement and edema control.
  • Discussion of the limitations in available evidence for chronic ulcer management.

Main Results:

  • Systematic conservative approaches demonstrate rapid healing for most leg ulcers.
  • Chronic recalcitrant ulcers present a significant clinical challenge.

Conclusions:

  • Conservative management is effective for the majority of leg ulcers in sickle cell anemia and S/beta-thalassemia.
  • Further controlled clinical trials are needed to define optimal treatment for chronic leg ulcers.

Related Experiment Videos