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Related Experiment Videos

"Normal pressure" pseudotumor cerebri

J P Green1, N J Newman, Z N Stowe

  • 1Department of Ophthalmology, Emory University, Atlanta, Georgia, USA.

Journal of Neuro-Ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society
|December 1, 1996
PubMed
Summary

Pseudotumor cerebri (PTC) may occur without elevated intracranial pressure (ICP). This case report shows a patient with PTC symptoms improved with standard treatment, even with normal ICP levels.

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Area of Science:

  • Neurology
  • Ophthalmology

Background:

  • Pseudotumor cerebri (PTC), also known as idiopathic intracranial hypertension, is typically diagnosed with elevated intracranial pressure (ICP).
  • Standard diagnostic criteria for PTC often rely on documented ICP measurements, posing challenges for atypical presentations.

Observation:

  • This case report details a patient exhibiting clinical signs and symptoms consistent with PTC, including headache, disc edema, and visual field loss.
  • Despite lacking a documented elevated ICP, the patient underwent treatment for PTC over a 28-month period.
  • The patient's symptoms, including clinical depression, showed significant improvement following standard PTC therapies, including optic nerve sheath fenestration (ONSF).

Findings:

  • PTC can manifest clinically without meeting the standard criteria for elevated ICP.

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  • Certain individuals may be more sensitive to lower ICP levels, developing PTC syndrome.
  • Standard PTC treatments can be effective even in cases without confirmed ICP elevation.

    • Implications:

    • This case suggests that clinical evaluation for PTC should consider presentations lacking documented ICP elevation.
    • Lower ICP thresholds might be relevant for diagnosing PTC in susceptible individuals.
    • Clinical depression may represent a previously unrecognized minor symptom of PTC, warranting further investigation.