Related Experiment Video
Updated: Aug 19, 2026

Quantitative and Qualitative Examination of Particle-particle Interactions Using Colloidal Probe Nanoscopy
Published on: July 18, 2014
Influence of surface free energies and cohesion parameters on pharmaceutical material interaction
Purpose:
The aim of this study was to perform simulations of the influence of surface free energies and cohesion parameters on various interaction parameters within binary systems.
Methods:
Using predictive equations derived from surface free energies and cohesion parameters originally proposed by Wu (2, 3) and by Rowe (4), values of interfacial tension, spreading and reduced spreading coefficients, interaction parameter and strength of interaction were simulated by means of a data processor. The influence of polar and disperse fractions of the two interacting materials was also examined.
Results:
From the simulations, boundary conditions could be drawn: minimum interfacial tension, positive spreading coefficient, reduced spreading coefficient superior to unity, maximum value of the interaction parameter or of the strength of interaction.
Conclusions:
Simulations of the various parameters will help the formulator to select proper materials, eg. an agent that will efficiently bind some powdered substrate, a film-forming agent that will properly coat given cores or a material that will enhibit high interaction with a substrate.
Related Concept Videos
Surface Tension, Capillary Action, and Viscosity
The various IMFs between identical molecules of a substance are examples of cohesive forces. The molecules within a liquid are surrounded by other molecules and are attracted equally in all directions by the cohesive forces within the liquid. However, the molecules on the surface of a liquid are attracted only by about one-half as many molecules. Because of the unbalanced molecular attractions on the surface molecules, liquids contract to form a shape that minimizes the number...
Surface Tension
Factors Influencing Drug Absorption: Pharmaceutical Parameters
Theories of Dissolution: The Danckwerts' Model and Interfacial Barrier Model
Factors Affecting Dissolution: Particle Size and Effective Surface Area
Surface Tension of Fluid
Surface tension varies with...

