Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cranial MR imaging in Wilson's disease

A D King1, J M Walshe, B E Kendall

  • 1Department of Radiology, Middlesex Hospital, London, England.

AJR. American Journal of Roentgenology
|December 1, 1996
PubMed
Summary

Cranial MRI reveals widespread abnormalities in Wilson's disease patients, particularly in the basal ganglia and brainstem. Longer disease duration correlates with less severe MRI signal changes, suggesting copper accumulation impacts imaging findings.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Correlation between head and neck radiologists reporting on extranodal extension detected on radiological imaging: A head and neck cancer international group multinational study.

Oral oncology·2026
Same author

Imaging features of non-nasopharyngeal lymphoepithelial carcinoma of the head and neck.

Clinical radiology·2025
Same author

Imaging of extranodal extension: why is it important in head and neck cancer?

ESMO open·2025
Same author

Volumetric measurement to evaluate treatment response to induction chemotherapy on MRI outperformed RECIST guideline in outcome prediction in advanced nasopharyngeal carcinoma.

ESMO open·2024
Same author

Pseudo fat-saturation and orbital lipolysis in cancer cachexia: a diagnostic trap.

Hong Kong medical journal = Xianggang yi xue za zhi·2024
Same author

Magnetic Arctic Circle in a Square Ice Qubit Lattice.

Physical review letters·2023

Area of Science:

  • Neurology
  • Radiology
  • Medical Imaging

Background:

  • Wilson's disease is a genetic disorder of copper metabolism.
  • Neurological manifestations are common and can be severe.
  • Cranial Magnetic Resonance (MR) imaging is a key tool for evaluating neurological involvement.

Purpose of the Study:

  • To characterize the spectrum of cranial MR imaging abnormalities in Wilson's disease.
  • To correlate MR findings with clinical disease severity and duration.
  • To assess the utility of MR imaging in monitoring treatment response.

Main Methods:

  • Twenty-five patients with Wilson's disease underwent brain MR imaging.
  • Utilized conventional spin-echo, phase mapping, and multiple-echo sequences.

Related Experiment Videos

  • Correlated imaging findings with clinical data and follow-up assessments.

    • Main Results:

    • MR imaging abnormalities were detected in 88% of patients.
    • Commonly affected areas included the basal ganglia (putamen, thalami) and brainstem (midbrain, pons).
    • A significant inverse relationship was observed between signal intensity changes and disease duration.

    Conclusions:

    • Cranial MR imaging demonstrates diverse abnormalities in Wilson's disease, predominantly in the basal ganglia and brainstem.
    • Paramagnetic effects of copper were evident in untreated patients.
    • MR imaging has limited value for monitoring treatment response, though disease duration influences imaging findings.