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Progressive outer retinal necrosis after bone marrow transplantation

J M Lewis1, Y Nagae, Y Tano

  • 1Department of Ophthalmology, Osaka University Medical School. jlewis@med.wayne.edu

American Journal of Ophthalmology
|December 1, 1996
PubMed
Summary

Progressive outer retinal necrosis can affect immunosuppressed patients, not just those with acquired immunodeficiency syndrome. This case highlights the condition in a patient receiving bone marrow transplantation for graft-versus-host disease.

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Area of Science:

  • Ophthalmology
  • Immunology
  • Hematology

Background:

  • Progressive outer retinal necrosis (PORN) is a severe viral retinitis.
  • Typically associated with acquired immunodeficiency syndrome (AIDS).
  • This report details a case in a non-AIDS immunosuppressed patient.

Observation:

  • A human immunodeficiency virus-negative patient with graft-versus-host disease post-bone marrow transplant developed PORN.
  • Clinical presentation and disease progression were characteristic of PORN syndrome.
  • The patient's immunosuppression was due to treatment for graft-versus-host disease.

Findings:

  • The patient's ocular findings and disease course were consistent with PORN.
  • This indicates PORN can manifest in diverse immunosuppressive states.

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  • Viral retinitis diagnosis was confirmed through clinical presentation.

    • Implications:

    • PORN is not exclusive to individuals with AIDS.
    • Clinicians should consider PORN in any severely immunocompromised patient presenting with compatible retinal findings.
    • Early recognition and management are crucial for visual outcomes in PORN.