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Updated: Aug 19, 2026
Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer
Published on: September 18, 2020
Flow cytometric DNA analysis of gastric cancer that is invading the muscularis propria
H Mizunuma1, A Tsuchiya, Y Ando
1Department of Surgery II, Fukushima Medical College, Japan.
Objective:
To find out if there is any correlation between the DNA aneuploidy in gastric cancer that is invading the muscularis propria and survival.
Design:
Retrospective study.
Setting:
Teaching hospital, Japan.
Subjects:
52 patients who underwent gastric resection for gastric cancer that was invading the muscularis propria, and for whom clinical follow-up data were available.
Interventions:
Flow cytometric measurement of DNA in paraffin-embedded tissue.
Main Outcome Measures:
Correlation between survival and clinicopathological variables including ploidy.
Results:
22 (42%) of the cases were aneuploid and 30 (58%) were diploid. The lymph node status and DNA ploidy were the significant prognostic variables, but a multivariate analysis showed that only DNA ploidy was significant.
Conclusions:
Nuclear DNA ploidy is an independent prognostic factor in gastric cancer that is invading the muscularis propria.
