Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A highly variable STR at the D12S391 locus

M V Lareu1, C Pestoni, M Schürenkamp

  • 1Institute of Legal Medicine, Faculty of Medicine, Santiago de Compostela, Spain.

International Journal of Legal Medicine
|January 1, 1996
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Non-coding Regulatory Variants in ASD (Autism Spectrum Disorders) Disrupt CTCF Domains and Shape Cell-Type-Specific Neurodevelopmental Landscapes Revealed by Single-Cell Analyses and Cortical Organoids.

Research square·2026
Same author

DNA tests for ancestry and phenotype inference applied to the UK Metropolitan Police Operation Minstead: The investigation of serial sex offender Delroy Grant.

Forensic science international. Genetics·2026
Same author

Loss of PGC1α drives extracellular matrix remodelling in prostate cancer through CTHRC1.

bioRxiv : the preprint server for biology·2026
Same author

Descriptive transcriptomic profiling differentiates oral leukoplakia from proliferative verrucous leukoplakia and reveals distinct molecular signatures.

Medicina oral, patologia oral y cirugia bucal·2025
Same author

Alternative splicing analysis in a Spanish ASD (Autism Spectrum Disorders) cohort: in silico prediction and characterization.

Scientific reports·2025
Same author

Unraveling the three-dimensional (3D) genome architecture in Neurodevelopmental Disorders (NDDs).

Neurogenetics·2024
Same journal

Deep Learning-Based Panoramic Radiograph Retrieval from Antemortem Images for Forensic Identification.

International journal of legal medicine·2026
Same journal

Forensic age estimation using knee MRI: application of the Vieth staging system in a French population.

International journal of legal medicine·2026
Same journal

A swab and wetting agent combination investigation for enhanced touch DNA recovery: A step towards standardisation.

International journal of legal medicine·2026
Same journal

Paternal lineage diversity in the Sikh males of Sri Ganganagar, Rajasthan through 27 Y-STRs.

International journal of legal medicine·2026
Same journal

Testing the accuracy of Cameriere's original and European formulae radiographic method of dental age estimation.

International journal of legal medicine·2026
Same journal

Machine learning algorithms in the estimation of sex from 3DCT-generated cranial and pelvic measurements.

International journal of legal medicine·2026
See all related articles

The D12S391 short tandem repeat (STR) locus is highly polymorphic, featuring 24 alleles and a heterozygosity of 0.9. Its simple yet complex structure makes it ideal for forensic and genetic identification applications.

Area of Science:

  • Forensic genetics
  • Population genetics
  • Molecular biology

Background:

  • Short tandem repeats (STRs) are crucial markers in genetic analysis.
  • Understanding STR locus diversity is essential for forensic applications.
  • The D12S391 locus has potential for population studies.

Purpose of the Study:

  • To characterize the allelic diversity and structure of the STR D12S391 locus.
  • To evaluate the suitability of D12S391 for forensic and genetic purposes.

Main Methods:

  • Sequencing of 103 DNA fragments from the D12S391 locus.
  • Analysis of allele frequencies and repeat structures.
  • Calculation of heterozygosity within the studied population.

Main Results:

Related Experiment Videos

  • Identified 24 distinct alleles at the D12S391 locus, grouped into 12 allelic classes.
  • Determined a consensus structure of (AGAT)8-17(AGAC)6-10(AGAT)0-1 repeats.
  • Observed a high heterozygosity rate of 0.9, indicating significant polymorphism.
  • Found that alleles > 225 bp exhibit a more complex structure with both (AGAT) and (AGAC) motifs.

Conclusions:

  • The D12S391 STR locus is highly polymorphic and exhibits significant genetic diversity.
  • The locus possesses a relatively simple yet informative repeat structure, suitable for forensic analysis.
  • High heterozygosity and structural characteristics make D12S391 a valuable tool for forensic identification and population genetics studies.