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Decrease in sigma but no increase in striatal dopamine D4 sites in schizophrenic brains

D M Helmeste1, S W Tang, W E Bunney

  • 1Department of Psychiatry, University of California at Irvine, 92697, USA.

European Journal of Pharmacology
|October 31, 1996
PubMed
Summary
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[3H]Nemonapride binding reveals lower sigma receptor levels in schizophrenic brains. Dopamine D4 receptor differences were not observed between schizophrenic and control brain tissues using this radioligand.

Area of Science:

  • Neuroscience
  • Psychiatry
  • Pharmacology

Background:

  • Schizophrenia is a complex psychiatric disorder with debated neurobiological underpinnings.
  • Sigma receptors and dopamine D4 receptors are implicated in schizophrenia pathophysiology.
  • [3H]Nemonapride is a radioligand used to study these receptor systems.

Purpose of the Study:

  • To investigate the differential binding of [3H]Nemonapride to sigma and dopamine receptors in post-mortem schizophrenic brain tissues.
  • To compare sigma and dopamine D4 receptor binding between schizophrenic patients and healthy controls.

Main Methods:

  • Utilized post-mortem brain tissues from schizophrenic patients and matched controls.
  • Employed [3H]Nemonapride radioligand binding assays.
  • Used a subtraction method ([3H]nemonapride minus [3H]raclopride) to isolate dopamine D4 receptor binding.

Related Experiment Videos

Main Results:

  • [3H]Nemonapride binding to sigma receptors was significantly decreased in schizophrenic brain tissues compared to controls.
  • No significant differences in striatal dopamine D4/D4-like receptor binding were detected between schizophrenic and control groups.

Conclusions:

  • Sigma receptor binding alterations may play a role in schizophrenia.
  • [3H]Nemonapride binding is sensitive to assay conditions, differentially labeling sigma and dopamine receptor sites.
  • Dopamine D4 receptors do not appear to be differentially affected in the schizophrenic brains studied.