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Psoralen plus UVA protocol for Compositae photosensitivity

D A Burke1, G Corey, F J Storrs

  • 1Department of Dermatology, Oregon Health Sciences University, Portland, USA.

American Journal of Contact Dermatitis : Official Journal of the American Contact Dermatitis Society
|September 1, 1996
PubMed
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A new prednisone-assisted psoralen plus UVA (PUVA) therapy outpatient regimen effectively treated severe photosensitivity caused by Compositae plants. This protocol resolved chronic dermatitis in two patients, with one remaining clear for 18 months.

Area of Science:

  • Dermatology
  • Photobiology
  • Toxicology

Background:

  • Sesquiterpene lactones in Compositae plants can cause severe photosensitivity and persistent light reactions.
  • Managing this hypersensitivity is challenging, often necessitating inpatient care.
  • Existing psoralen plus UVA (PUVA) therapy protocols lack specific outpatient guidelines for Compositae-induced photosensitivity.

Observation:

  • Two male patients with chronic, photodistributed dermatitis unresponsive to prior treatments were studied.
  • The patients exhibited severe photosensitivity attributed to Compositae plant exposure.

Findings:

  • A novel prednisone-assisted PUVA outpatient protocol was developed.
  • This regimen involved weekly decrements in prednisone dosage concurrent with escalating PUVA doses.

Related Experiment Videos

  • Both participants showed significant resolution of their previously intractable eruptions.

    • Implications:

    • The developed protocol offers an effective outpatient treatment for Compositae photosensitivity.
    • This approach successfully managed chronic photodermatitis, demonstrating sustained remission in one case.
    • The findings suggest a viable alternative to hospitalization for managing severe plant-induced photosensitivity.