Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Antileukotriene therapy for asthma

J S Larsen¹, S K Jackson

¹College of Pharmacy, University of Minnesota, Minneapolis, USA.

American Journal of Health-System Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists

|December 1, 1996

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Deep, rapid, and durable prostate-specific antigen decline with apalutamide plus androgen deprivation therapy is associated with longer survival and improved clinical outcomes in TITAN patients with metastatic castration-sensitive prostate cancer.

Annals of oncology : official journal of the European Society for Medical Oncology·2023

Same author

Lysophosphatidylcholine acyltransferase 2 (LPCAT2) co-localises with TLR4 and regulates macrophage inflammatory gene expression in response to LPS.

Scientific reports·2020

Same author

Mass transport of lipopolysaccharide induced H<sub>2</sub>O<sub>2</sub> detected by an intracellular carbon nanoelectrode sensor.

Bioelectrochemistry (Amsterdam, Netherlands)·2020

Same author

Real-time bacterial detection with an intracellular ROS sensing platform.

Biosensors & bioelectronics·2019

Same author

Electrochemical communication with the inside of cells using micro-patterned vertical carbon nanofibre electrodes.

Scientific reports·2016

Same author

The expression of Toll-like receptor 4, 7 and co-receptors in neurochemical sub-populations of rat trigeminal ganglion sensory neurons.

Neuroscience·2015

New anti-leukotriene (LT) agents show promise for asthma treatment by targeting inflammation. These therapies, including receptor antagonists and enzyme inhibitors, may become key components of multidrug regimens for managing asthma effectively.

Area of Science:

Pulmonary Medicine
Pharmacology
Inflammation Research

Background:

Asthma pathophysiology research increasingly focuses on inflammation, moving beyond bronchoconstriction.
Leukotrienes (LTs) are recognized as key mediators in the inflammatory cascade of asthma.

Purpose of the Study:

To review the role of leukotrienes in asthma.
To describe research and development of anti-leukotriene agents for asthma therapy.

Main Methods:

Investigated three primary approaches to inhibit leukotriene activity: 5-lipoxygenase inhibition, 5-lipoxygenase-activating protein inhibition, and LTD4-receptor antagonism.
Reviewed clinical trial data for investigational agents like zileuton, MK-591, zafirlukast, pranlukast, and verlukast.

Main Results:

Related Experiment Videos

Orally administered anti-LT agents demonstrate effectiveness, particularly in mitigating early asthmatic responses to allergens.
Adverse effect profiles are generally low, with elevated liver enzymes noted as a primary concern, especially with zileuton.

Conclusions:

Anti-leukotriene agents represent a potentially valuable therapeutic modality for asthma.
Further large-scale and comparative trials are needed to establish the definitive role of these agents.
Anti-LT drugs are likely to be integrated into comprehensive, multidrug treatment strategies for asthma management.