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Related Experiment Videos

Heart transplantation: a single-center experience

M Pasic1, M Loebe, M Hummel

  • 1Klinik für Herz-, Thorax- und Gefässchirurgie, Deutsches Herzzentrum Berlin, Germany.

The Annals of Thoracic Surgery
|December 1, 1996
PubMed
Summary

Heart transplantation is effective for end-stage heart failure, even with expanded donor and recipient criteria. Donor organ scarcity remains a significant challenge for this life-saving procedure.

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Area of Science:

  • Cardiology
  • Transplantation Medicine
  • Medical Technology

Background:

  • Heart transplantation criteria for recipients and donors have been expanded due to the procedure's success.
  • This study evaluates the single-center experience with heart transplantation for end-stage heart failure.

Purpose of the Study:

  • To assess the outcomes of heart transplantation with broadened donor and recipient criteria.
  • To evaluate the effectiveness of ventricular assist devices as a bridge to heart transplantation.

Main Methods:

  • A retrospective analysis of 1,413 patients undergoing heart transplantation between April 1986 and January 1996.
  • Ventricular assist devices (VADs) were used in 173 patients as a bridge to transplantation, with a maximum support duration of 572 days.

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Main Results:

  • 891 patients received heart transplants; 522 died awaiting organs. Average wait time was 107 days.
  • Recipient age averaged 44 years, with donors up to 69 years. 48% of VAD patients underwent transplantation.
  • 30-day mortality was 14%; 1, 5, and 10-year survival rates were 80%, 59%, and 50%. 94% achieved NYHA class I/II at 1 year.

Conclusions:

  • Heart transplantation remains effective for end-stage heart failure despite wider selection criteria.
  • A significant gap between donor organ availability and patient need limits the therapeutic approach.