Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Extracorporeal circulation, hemocompatibility, and biomaterials

G Janvier1, C Baquey, C Roth

  • 1Biomaterial Research Unit (INSERM U.306), Centre Hospitalier Universitaire de Bordeaux, France.

The Annals of Thoracic Surgery
|December 1, 1996
PubMed
Summary

Newer cardiopulmonary bypass circuits with heparinized materials reduce inflammation during cardiac surgery but offer limited clinical benefits beyond extended support. Safe use requires full heparinization.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Criteria for the use of plasmapheresesis in optic neuritis: A practice review from French expert centers.

Revue neurologique·2025
Same author

Performance comparison of a previously validated microhaplotype panel and a forensic STR panel for DNA mixture analysis.

Forensic science international. Genetics·2024
Same author

Lean mass sparing in resistance-trained athletes during caloric restriction: the role of resistance training volume.

European journal of applied physiology·2022
Same author

Whole-body [<sup>18</sup>F]-FDG-PET/MRI for staging of pediatric non-Hodgkin lymphoma: first results from a single-center evaluation.

EJNMMI research·2021
Same author

A Theoretical Investigation of the Configurations (3<i>d</i> + 4<i>s</i>)<sup>4</sup>4<i>p</i> in Neutral Vanadium (V i).

Journal of research of the National Bureau of Standards. Section A, Physics and chemistry·2020
Same author

A Theoretical Investigation of the Configurations (3<i>d</i> + 4<i>s</i>)<sup>5</sup> 4<i>p</i> in Neutral Chromium (Cr I).

Journal of research of the National Bureau of Standards. Section A, Physics and chemistry·2020

Area of Science:

  • Cardiovascular Surgery
  • Biomaterials Science
  • Hemodynamics

Background:

  • Extracorporeal circulation is essential for most cardiac surgeries.
  • Blood contact with non-endothelial surfaces in cardiopulmonary bypass circuits triggers harmful systemic reactions.

Purpose of the Study:

  • To review patient responses to extracorporeal circulation.
  • To discuss blood-circuit interactions, including material contact, mechanical, and rheologic factors.
  • To evaluate the clinical benefits of newer, hemocompatible materials and heparinized circuits.

Main Methods:

  • Review of patient responses to extracorporeal circulation.
  • Discussion of blood-material interactions, mechanical, and rheologic aspects.
  • Presentation of theoretical benefits of new materials and review of clinical experience with heparinized circuits.

Related Experiment Videos

Main Results:

  • Patient response to extracorporeal circulation involves more than hemostasis derangement, including significant inflammatory responses.
  • Inflammation is influenced by circuit rheology and surface properties.
  • Heparinized circuits reduce inflammation, but clinical benefits are mainly for extended cardiopulmonary support; they do not reduce allogeneic transfusions.

Conclusions:

  • The ideal extracorporeal circuit material and design remain under investigation.
  • Current advanced heparinized materials provide real, yet limited, clinical advantages.