Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Fluctuating asymmetry and disorders of developmental origin

C T Naugler1, M D Ludman

  • 1Department of Pediatrics, Dalhousie University, Halifax, Nova Scotia, Canada.

American Journal of Medical Genetics
|December 2, 1996
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Current practices of adjunctive therapy for pertussis at six Canadian tertiary care pediatric hospitals.

The Canadian journal of infectious diseases = Journal canadien des maladies infectieuses·2012
Same author

Multiple metachromatic leucodystrophy alleles in an unaffected subject: a case of dispermic chimaerism.

Journal of medical genetics·2001
Same author

Development and validation of an improving prescribing in the elderly tool.

The Canadian journal of clinical pharmacology = Journal canadien de pharmacologie clinique·2000
Same author

Absence of fragile X syndrome in Nova Scotia.

Journal of medical genetics·2000
Same author

Manifestations and treatment of Schimke immuno-osseous dysplasia: 14 new cases and a review of the literature.

European journal of pediatrics·2000
Same author

More on breast cancer guidelines.

CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne·1998

Increased morphological asymmetry, or fluctuating asymmetry, may indicate developmental disorders. This potential risk marker

Area of Science:

  • Developmental Biology
  • Human Genetics
  • Evolutionary Biology

Background:

  • Developmental homeostasis ensures symmetrical growth, but environmental or genetic stress can disrupt this.
  • Increased bilateral asymmetry, termed fluctuating asymmetry, is a potential indicator of developmental instability.
  • Fluctuating asymmetry may serve as a risk marker for developmental disorders if stress or genetic factors are shared.

Purpose of the Study:

  • To explore the potential of fluctuating asymmetry as a risk marker for developmental disorders.
  • To investigate the link between environmental/genetic stress, developmental stability, and disorder predisposition.

Main Methods:

  • Review of existing literature associating fluctuating asymmetry with developmental disorders.
  • Analysis of theoretical frameworks for shared causes of developmental disorders and asymmetry.

Related Experiment Videos

Main Results:

  • Previous studies suggest associations between increased fluctuating asymmetry and developmental disorders.
  • The utility of fluctuating asymmetry as a risk marker remains unestablished.
  • A lack of reported odds ratios hinders the assessment of its clinical usefulness.

Conclusions:

  • Fluctuating asymmetry shows potential as a risk marker for developmental disorders.
  • Further research is needed to establish its reliability and clinical applicability.
  • Quantifying the association with odds ratios is crucial for future assessments.