Related Experiment Video
Updated: Aug 6, 2026
08:02
Th17 Inflammation Model of Oropharyngeal Candidiasis in Immunodeficient Mice
Published on: February 18, 2015
Psoriasis: pathophysiology and oral manifestations
J F Zhu1, M J Kaminski, D R Pulitzer
1Department of Pediatric Dentistry, University of Texas Health Science Center at San Antonio 78284-7888, USA.
Oral Diseases
|June 1, 1996
Summary
Psoriasis, a chronic inflammatory skin condition, often presents with oral symptoms like tongue and gum lesions. While treatments manage symptoms, a cure for psoriasis remains elusive.
Area of Science:
- Dermatology
- Oral Medicine
- Immunology
Background:
- Psoriasis is a chronic inflammatory skin disease with genetic links, affecting 1-3% of the global population.
- It causes significant disability, social, and economic burdens, yet its mechanisms are not fully understood.
- Research continues to explore the etiology and tissue destruction in psoriasis.
Purpose of the Study:
- To review current literature on psoriasis.
- To specifically highlight the oral manifestations of psoriasis.
- To provide updated information on psoriasis management.
Main Methods:
- Literature review of existing studies on psoriasis.
- Focus on research detailing oral symptoms associated with the condition.
- Synthesis of information regarding treatment strategies.
Main Results:
- Common oral signs include geographic tongue, fissure tongue, and gingival/mucosal lesions.
- Inflammatory temporomandibular joint lesions are reported in fewer than 5% of psoriasis patients.
- Topical and systemic treatments offer symptom relief but not a cure.
Conclusions:
- Psoriasis frequently involves oral manifestations that require attention.
- Current treatments for psoriasis are palliative, not curative.
- Further research is needed to understand and potentially cure psoriasis.
Related Concept Videos
01:23Skin Diseases and Disorders
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
01:28Peptic Ulcer Disease II: Pathophysiology
Peptic Ulcer Disease (PUD) is characterized by the development of ulcers in the stomach or duodenal mucosa. Its pathophysiology is complex, involving a balance between damaging and protective elements.
Damaging agents such as Helicobacter pylori, gastric acid, pepsin, and nonsteroidal anti-inflammatory drugs (NSAIDs) can weaken the mucosal defense, allowing hydrogen ions to infiltrate back and harm epithelial cells.
Damaging agents such as Helicobacter pylori, gastric acid, pepsin, and nonsteroidal anti-inflammatory drugs (NSAIDs) can weaken the mucosal defense, allowing hydrogen ions to infiltrate back and harm epithelial cells.
01:27The Oral Microbiota
The oral microbiome includes a complex ecosystem comprising over 700 microbial species, identified through genomic sequencing and culture-based analyses to date. This community includes a core microbiome, found universally among individuals, and a variable component influenced by environmental factors such as diet, lifestyle, and host genetics. Site-specific conditions, including oxygen gradients, pH levels, and nutrient availability, determine the spatial distribution of these microorganisms...
01:25Introduction to Language of Pathophysiology l
Pathophysiology investigates how biological mechanisms—typically starting at the cellular level—disrupt normal bodily functions. It bridges anatomy and physiology to explain the progression of disease. With this foundation, it is important to understand the following key terms used to describe disease processes: Diagnosis:The process of identifying a disease using clinical evaluation, including signs (objective evidence like rashes), symptoms (subjective experiences like pain), laboratory test...
01:19Multiple Sclerosis l: Introduction
Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...
01:20Inflammatory Bowel Disease IV: Clinical Manifestations
Inflammatory bowel disease (IBD) encompasses two major chronic disorders—ulcerative colitis and Crohn’s disease—each characterized by relapsing episodes of gastrointestinal inflammation. Although they share certain clinical features, their patterns of involvement and manifestations differ in ways that aid diagnosis and guide management.Ulcerative ColitisUlcerative colitis is limited to the colon and rectum and involves continuous inflammation of the mucosal layer. The disease course is marked...