Related Experiment Videos
Origins of cementum
L Hammarström1, I Alatli, C D Fong
1Center for Oral Biology, Karolinska Institute, Stockholm, Sweden.
Oral Diseases
|March 1, 1996
Summary
Hertwig's epithelial root sheath plays a key role in forming both acellular and cellular cementum. Its interaction with dental follicle cells and mantle dentin mineralization influences cementum development.
Area of Science:
- Dental Histology
- Tooth Development
- Biomineralization
Background:
- Divergent opinions exist regarding the function of Hertwig's epithelial root sheath (HERS) in cementum formation.
- Recent evidence suggests HERS actively participates in both acellular and cellular cementum development.
Purpose of the Study:
- To review and discuss the role of Hertwig's epithelial root sheath in cementum formation.
- To synthesize current evidence on HERS involvement in acellular and cellular cementum development.
Main Methods:
- Review of existing scientific literature and experimental studies.
- Analysis of experimental data involving 1-hydroxyethylidene-1, 1-bisphosphonate (HEBP) and its effect on dentin mineralization and HERS.
Main Results:
- HERS actively contributes to the formation of both acellular and cellular cementum.
- Acellular cementum development is linked to the secretion of enamel-related proteins by HERS cells.
- Cellular cementum matrix formation is induced by the exposure of the inner HERS layer to dental follicle mesenchymal cells.
- HEBP studies indicate that mantle dentin mineralization must precede acellular cementum formation.
Conclusions:
- HERS is crucial for cementum formation, influencing both acellular and cellular types.
- The process involves specific molecular signals and cellular interactions.
- Inhibition of dentin mineralization can disrupt normal cementum development pathways.