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Colorectal cancer: the challenge

H Bleiberg1

  • 1Unité de Gastroentérologie et de Chimiotherapie, Institut Jules Bordet, Brussels, Belgium.

European Journal of Cancer (Oxford, England : 1990)
|January 1, 1996
PubMed
Summary

Colorectal cancer treatment has advanced with chemotherapy, including 5-fluorouracil (5-FU) and newer agents. Improved patient referral and consistent treatment approaches are crucial for better outcomes in advanced colorectal cancer.

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Area of Science:

  • Oncology
  • Gastroenterology

Background:

  • Colorectal cancer is a leading cause of cancer-related death globally, with highest incidence in Western countries.
  • Surgery is the primary treatment for localized tumors, with chemotherapy essential for advanced or metastatic disease.

Purpose of the Study:

  • To review the current treatment landscape for colorectal cancer.
  • To highlight the evolution of chemotherapy agents and their impact on patient outcomes.
  • To emphasize the need for improved treatment strategies and patient management.

Main Methods:

  • Review of established and emerging treatments for colorectal cancer.
  • Analysis of the efficacy of 5-fluorouracil (5-FU) and its biomodulation.
  • Discussion of novel therapeutic agents and treatment approaches.

Main Results:

  • 5-fluorouracil (5-FU) has been a standard treatment for advanced colorectal cancer, with response rates below 15%.
  • Biomodulation of 5-FU with leucovorin improved response rates and palliative effects, with modest survival benefits.
  • Adjuvant therapy with 5-FU and levamisole or leucovorin showed a 10% increase in survival post-surgery.
  • Newer agents like thymidylate synthase inhibitors, CPT-11, and oxaliplatin show promise.

Conclusions:

  • Despite progress, a significant proportion of colorectal cancer patients remain undertreated.
  • Novel therapies and optimized treatment strategies, including increased patient referral, are needed to improve outcomes for advanced colorectal cancer.

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