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Lassa fever: response to an imported case

R M Zweighaft, D W Fraser, M A Hattwick

The New England Journal of Medicine

|October 13, 1977

Summary

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No Lassa fever transmission occurred in contacts after a Peace Corps worker returned from Sierra Leone. Intensive surveillance and isolation procedures effectively contained the potential outbreak of this highly fatal disease.

Area of Science:

Epidemiology
Infectious Diseases
Public Health

Background:

A Peace Corps worker returning from Sierra Leone in 1976 presented with an undiagnosed illness, later identified as Lassa fever.
This case represented a potential introduction of a highly fatal communicable disease into the United States.

Observation:

552 contacts exposed to the patient before isolation were monitored for 21 days.
A subsequent serologic survey of high-risk contacts showed no evidence of infection.

Findings:

No Lassa fever cases developed among the monitored contacts.
The intensive surveillance and isolation protocols were successful in preventing disease transmission.

Implications:

The implemented procedures for patient isolation, contact identification, surveillance, and laboratory specimen handling were effective.

Related Experiment Videos

These containment strategies can be adapted for future introductions of highly contagious diseases.