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Related Experiment Videos

Peripheral CD4+ CD8- gammadelta T cell lymphoma: a case report with multiparameter analyses

R Ichinohasama1, I Miura, T Takahashi

  • 1Department of Pathology, Tohoku University Hospital, Aoba-ku, Sendai, Japan.

Human Pathology
|December 1, 1996
PubMed
Summary

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This study describes a rare CD4+ T-cell receptor (TCR) gammadelta T-cell lymphoma. This unique subtype presents a less aggressive clinical course than other common forms.

Area of Science:

  • Hematology
  • Oncology
  • Immunology

Background:

  • T-cell receptor (TCR) gammadelta T-cell lymphomas are rare lymphoid malignancies.
  • Understanding their diverse phenotypes and clinical behaviors is crucial for diagnosis and treatment.

Observation:

  • A 72-year-old man presented with CD4+ TCR gammadelta T-cell lymphoma affecting cervical lymph nodes.
  • Flow cytometry revealed a unique phenotype: CD3+ CD4+ CD8- CD7- CD5+ CD2++ TCR gammadelta1+.
  • Cytogenetic analysis identified specific chromosomal abnormalities, including del(1)(p11) and i(17)(q10).

Findings:

  • The lymphoma demonstrated an initial response to chemotherapy and irradiation but relapsed.
  • Gene rearrangements in TCR gamma and delta chains were observed, with aberrant TCR beta.

Related Experiment Videos

  • The unique CD4+ phenotype and clinical course suggest a distinct subtype of gammadelta T-cell lymphoma.

    • Implications:

    • This case highlights a potential new subtype of gammadelta T-cell lymphoma characterized by CD4 positivity.
    • The observed clinical course, while relapsing, was less aggressive than typical subtypes.
    • Further research into this specific subtype may refine diagnostic criteria and therapeutic strategies for T-cell lymphomas.