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Effect of oxytocin on growth hormone release in vitro
A L Hulting1, E Grenbäck, J Pineda
1Department of Endocrinology, Karolinska Hospital, Stockholm, Sweden.
Abstract:
The effect of oxytocin (OT) on growth hormone (GH) secretion was investigated using dispersed rat anterior pituitary cells. OT dose-dependently inhibited GH secretion as well as GHRH-stimulated GH release. The inhibitory actions of OT on GH release were totally abolished by pretreatment with the OT-antagonist VAP 259. The peptides galanin and cholecystokinin did not affect the OT-induced inhibition on basal or GHRH-stimulated GH release. Several possible mechanisms by which OT may influence GH release are discussed.
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