Direct renovascular effect of somatostatin in the dog

Recently, effects of somatostatin on the renal function have been described and the vasoactive properties of the peptide were proposed to contribute to this action. However, the available data on its effect in the renal vascular bed are very controversial. Therefore, we investigated the effect of local intaarterial somatostatin boluses in a wide range of doses (5 x 10(-11) - 5 x 10(-5) g) on the renal blood flow (RBF) in anesthetized dogs. RBF was measured by an electromagnetic flow probe. Somatostatin did not influence blood pressure or heart rate. RBF exhibited a significant, dose-dependent fall (ranging from 11.6 +/- 11.9% to 31.9 +/- 17.3%), with a threshold at a dose of 5 x 10(-10) g. These results offer conclusive evidence for the contribution of somatostatin-induced direct renal vasoconstriction to its renal effects, in addition to the demonstrated modulation of other vasoactive systems and tubular functions.