Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Permissive hypercapnia. From choice to unavoidable decision]

C Perret, F Feihl

    Presse Medicale (Paris, France : 1983)
    |October 19, 1996
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Mapping of Dietary Interventions Beneficial in the Prevention of Secondary Health Conditions in Spinal Cord Injured Population: A Systematic Review.

    The journal of nutrition, health & aging·2023
    Same author

    Fully endoscopic clipping of anterior circulation cerebral aneurysms through transpalpebral approach: One step closer to robotic neurovascular surgery?

    Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia·2021
    Same author

    Management of vascular and nonvascular complications following pancreas transplantation with interventional radiology.

    Diagnostic and interventional imaging·2020
    Same author

    Minilaparotomy-assisted transmesenteric approach for portal vein recanalization and transjugular intrahepatic portosystemic shunt in a non-cirrhotic patient with portal cavernoma.

    Diagnostic and interventional imaging·2020
    Same author

    Ultrasonographic guidance for portal vein access during transjugular intrahepatic portosystemic shunt (TIPS) placement.

    Diagnostic and interventional imaging·2019
    Same author

    Erratum to "Storage at room temperature does not change cisatracurium onset time: A prospective, randomized, double-blind controlled study [Ann. Fr. Anesth. Reanim. 31 (2012) 783-787].

    Anaesthesia, critical care & pain medicine·2018
    Same journal

    Predictive analytics and risk stratification models in internal medicine: from risk scores to real-time machine learning.

    Presse medicale (Paris, France : 1983)·2026
    Same journal

    Artificial Intelligence in skin disease therapeutics: from drug discovery to personalized treatment pathways.

    Presse medicale (Paris, France : 1983)·2026
    Same journal

    AI in clinical diagnostics in dermatology: applications, validation, and real-world use cases.

    Presse medicale (Paris, France : 1983)·2026
    Same journal

    Artificial Intelligence in medical research and publishing: progress, risks, and future perspectives.

    Presse medicale (Paris, France : 1983)·2026
    Same journal

    Ethical, legal, and regulatory challenges in AI-based healthcare tools.

    Presse medicale (Paris, France : 1983)·2026
    Same journal

    Decision-making for clinicians.

    Presse medicale (Paris, France : 1983)·2026
    See all related articles

    Controlled hypoventilation, or permissive hypercapnia, is a revised mechanical ventilation strategy for respiratory failure. This approach accepts higher carbon dioxide levels to prevent lung injury from overinflation, showing promise in asthma treatment.

    Area of Science:

    • Pulmonology
    • Critical Care Medicine
    • Respiratory Physiology

    Background:

    • Conventional mechanical ventilation techniques are being revised for respiratory failure in severe asthma and acute respiratory distress syndrome.
    • Heterogeneous lung lesions in these conditions cause uneven tidal volume distribution, leading to overdistension or exclusion and potential complications like barotrauma.

    Discussion:

    • Controlled hypoventilation, termed permissive hypercapnia, is a strategy to prevent mechanical ventilation-induced lung injury.
    • This technique involves restricting tidal volume and respiratory rate to achieve better lung mechanics while maintaining adequate oxygenation.
    • It accepts or provokes a degree of hypercapnia (elevated carbon dioxide) through alveolar hypoventilation.

    Key Insights:

    • Permissive hypercapnia effectively manages decompensated asthma by mitigating risks associated with traditional ventilation.

    Related Experiment Videos

  • Preliminary data suggest potential benefits in acute respiratory distress syndrome, but further validation is required.
  • The core principle is to prioritize lung protection over strict normalization of arterial carbon dioxide levels.

    • Outlook:

    • Further clinical trials are necessary to validate the efficacy and safety of permissive hypercapnia in acute respiratory distress syndrome.
    • This approach may represent a paradigm shift in managing heterogeneous lung diseases requiring mechanical ventilation.
    • Future research could explore optimal parameters and patient selection for this ventilation strategy.