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Strategies for Tracking Anastasis, A Cell Survival Phenomenon that Reverses Apoptosis
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Apoptosis induced by interleukin-12 measured by DNA electrophoresis and in situ end labeling in leukemia

K C Stine1, B A Warren, D L Becton

  • 1Arkansas Children's Hospital, Little Rock 72202, USA.

Annals of the New York Academy of Sciences
|October 31, 1996
PubMed
Abstract

No abstract available in PubMed .

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The Intrinsic Apoptotic Pathway01:31

The Intrinsic Apoptotic Pathway

Internal cellular stress, such as cellular injury or hypoxia, triggers intrinsic apoptosis. The B-cell lymphoma 2 (Bcl-2) family of proteins are the primary regulators of the intrinsic apoptotic pathway. For example, during DNA damage, checkpoint proteins, such as Ataxia Telangiectasia Mutated (ATM protein) and Checkpoints Factor-2 (Chk2) proteins, are activated. These proteins phosphorylate p53 which further activates pro-apoptotic proteins, such as Bax, Bak, PUMA, and Noxa, and inhibits...

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