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Related Experiment Videos

High flux plasma exchange using a modified rotating membrane system

A A Kaplan1, R A Bailey, C E Kew

  • 1Department of Medicine, University of Connecticut Health Center, Farmington 06032, USA.

ASAIO Journal (American Society for Artificial Internal Organs : 1992)
|November 1, 1996
PubMed
Summary
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A modified plasma exchange system with increased blood flow capability significantly reduced treatment time. This enhanced efficiency in plasma removal offers a clinically useful improvement for patients undergoing the procedure.

Area of Science:

  • Nephrology
  • Medical Devices
  • Cardiovascular System

Background:

  • Plasma exchange is a critical therapeutic apheresis technique.
  • Existing systems face limitations in blood flow rates, impacting procedure efficiency.
  • Optimizing blood flow is key to improving plasma exchange protocols.

Purpose of the Study:

  • To evaluate the impact of increased blood flow capability in a modified plasma exchange system.
  • To compare the efficiency and outcomes of the original system (OS) versus the updated system (US).
  • To assess changes in blood flow, plasma flow, removal rates, and treatment duration.

Main Methods:

  • A modified rotating filter system for plasma exchange was utilized.
  • 742 treatments were performed with the original system (OS) at 100 ml/min.

Related Experiment Videos

  • 327 treatments were performed with the updated system (US) at 150 ml/min.

    • Main Results:

    • The updated system (US) achieved significantly higher blood flows (145 ml/min vs. 98 ml/min) and plasma flows (98 ml/min vs. 65 ml/min).
    • Plasma removal rate increased significantly with the US (61 ml/min vs. 42 ml/min).
    • Mean treatment time decreased substantially from 76 minutes (OS) to 52 minutes (US) (p < 0.001).

    Conclusions:

    • Modification of the plasma exchange system to increase blood flow capability significantly enhances procedural efficiency.
    • The updated system offers a clinically useful reduction in treatment time without compromising plasma removal volume.
    • This advancement represents a substantial improvement in plasma exchange therapy delivery.