Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Tubulo-glomerular feedback in the rat

P C Churchill, M C Churchill, F D McDonald

    Nephron
    |January 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

    This study found that tubulo-glomerular feedback is not active in rats and angiotensin II does not control filtration. Single nephron GFR measurements confirm these findings in Sprague-Dawley rats.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Genetic susceptibility to renal injury in hypertension.

    Experimental nephrology·2001
    Same author

    Kidney-specific chromosome transfer in genetic hypertension: the Dahl hypothesis revisited.

    Kidney international·2001
    Same author

    Differential salt-sensitivity in the pathogenesis of renal damage in SHR and stroke prone SHR.

    American journal of hypertension·2001
    Same author

    The effects of housing enrichment on cardiovascular parameters in spontaneously hypertensive rats.

    Contemporary topics in laboratory animal science·2001
    Same author

    Heart failure alters the strength and mechanisms of the muscle metaboreflex.

    American journal of physiology. Heart and circulatory physiology·2000
    Same author

    Genetic isolation of a chromosome 1 region affecting susceptibility to hypertension-induced renal damage in the spontaneously hypertensive rat.

    Hypertension (Dallas, Tex. : 1979)·1999

    Area of Science:

    • Nephrology
    • Physiology
    • Renal Function

    Background:

    • Tubulo-glomerular feedback (TGF) is a mechanism regulating glomerular filtration rate (GFR).
    • Angiotensin II is a hormone implicated in renal function and blood pressure regulation.

    Purpose of the Study:

    • To investigate the role of tubulo-glomerular feedback in controlling single nephron GFR.
    • To determine the involvement of angiotensin II in regulating renal filtration.

    Main Methods:

    • Conventional micropuncture techniques were used in anesthetized Sprague-Dawley rats.
    • Single nephron GFR (snGFR) was measured at proximal and distal sites.
    • The effect of SQ20,881, an angiotensin II synthesis inhibitor, on snGFR was assessed.

    Main Results:

    Related Experiment Videos

    • Proximal snGFR was not significantly greater than distal snGFR, suggesting no active TGF.
    • Whole kidney GFR and distal snGFR were unaffected by SQ20,881 infusion.
    • Angiotensin II inhibition did not alter snGFR, indicating no role in filtration control under these experimental conditions.

    Conclusions:

    • Tubulo-glomerular feedback is not operative in Sprague-Dawley rats under the experimental conditions.
    • Angiotensin II does not play a significant role in controlling glomerular filtration in this model.
    • These findings challenge the established understanding of renal autoregulation mechanisms.