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Related Experiment Videos

Does delayed kidney graft function increase the risk of chronic rejection?

H Isoniemi1, S Lehtonen, K Salmela

  • 1IV Department of Surgery, Helsinki University Central Hospital, Finland.

Transplant International : Official Journal of the European Society for Organ Transplantation
|January 1, 1996
PubMed
Summary

Delayed graft function (DGF) in kidney transplants did not significantly impact long-term survival. However, DGF starting after two weeks in retransplants was linked to lower graft survival rates, excluding chronic rejection.

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Area of Science:

  • Nephrology
  • Transplantation Immunology
  • Clinical Medicine

Background:

  • Delayed graft function (DGF) is a common complication following kidney transplantation.
  • The long-term impact of DGF on renal graft survival, particularly concerning chronic rejection, requires further elucidation.

Purpose of the Study:

  • To investigate the association between delayed graft function (DGF) and subsequent renal graft loss due to chronic rejection.
  • To analyze the influence of the timing of graft function recovery on long-term transplant outcomes.

Main Methods:

  • A single-center study involving 829 first cadaveric renal transplants and 169 retransplantations.
  • Uniform protocols for organ procurement and post-transplant patient care were applied.
  • Graft survival rates were compared between patients with early graft function (EGF) and DGF, with DGF further categorized by onset timing.

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Main Results:

  • Delayed graft function (DGF) occurred in 34% of first transplants and 47% of retransplantations.
  • No significant differences in graft survival were observed between early graft function (EGF) and DGF groups for first transplants or retransplants.
  • In retransplants, DGF starting later than two weeks post-surgery was associated with significantly lower long-term graft survival rates compared to EGF, even when excluding other causes of graft loss.

Conclusions:

  • Delayed graft function (DGF) itself does not appear to significantly reduce long-term renal graft survival in first-time recipients.
  • The timing of graft function recovery is critical, especially in retransplantations, where delayed function beyond two weeks portends poorer outcomes.
  • Further research may be warranted to explore specific mechanisms linking late-onset DGF to reduced graft longevity in retransplant scenarios.