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Botulinum toxin--a possible new treatment for axillary hyperhidrosis
K O Bushara1, D M Park, J C Jones
1Department of Neurology, University of Wisconsin Hospital and Clinics, Madison 53792-5132, USA.
Clinical and Experimental Dermatology
|July 1, 1996
Summary
Botulinum toxin injections effectively block sweat glands, causing localized anhidrosis (inability to sweat). Doses of 50 units of botulinum toxin A (Botox) can abolish axillary sweating for up to 8 months.
Area of Science:
- Neurology
- Dermatology
- Pharmacology
Background:
- Botulinum toxin inhibits neuromuscular junctions and autonomic cholinergic fibers, including sympathetic nerves controlling sweat glands.
- Previous studies demonstrated botulinum toxin's localized anhidrotic effect.
Purpose of the Study:
- To determine the dosage, pattern, and duration of botulinum toxin's anhidrotic effect.
- To evaluate the efficacy of axillary injections of botulinum toxin for sweat control.
Main Methods:
- Seven healthy volunteers received subcutaneous injections of botulinum toxin.
- Two received injections on the hand (20 mouse units), and five received injections in one axilla (15-50 U of botulinum toxin A).
Main Results:
- Anhidrosis on the hand persisted for 11 months.
- Axillary sweating was abolished with 50 U of botulinum toxin A in two subjects and substantially reduced with 30 U in one subject.
- Effects lasted 6-8 months; lower doses (15-20 U) showed no effect. No significant side effects were noted.
Conclusions:
- Subcutaneous botulinum toxin injections cause chemodenervation of sweat glands.
- 50 U of botulinum toxin A can eliminate axillary sweating in individuals.
- This suggests a potential treatment for severe axillary hyperhidrosis.