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Related Experiment Videos

Plasma prolactin during lithium treatment

J Lanng Nielsen, A Amdisen, S Darling

    Neuropsychobiology
    |January 1, 1977
    PubMed
    Summary

    Lithium treatment for manic-depressive patients did not affect plasma prolactin levels or water and sodium balance. This study indicates lithium is not associated with prolonged prolactin elevation, unlike some other medications.

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    Area of Science:

    • Endocrinology
    • Psychopharmacology
    • Oncology

    Background:

    • Prolonged elevated plasma prolactin is linked to breast cancer risk.
    • Certain medications like phenothiazines and reserpine can cause elevated prolactin levels.
    • The effect of lithium on plasma prolactin requires further investigation.

    Purpose of the Study:

    • To investigate the association between changes in water and sodium balance during lithium treatment and plasma prolactin levels.
    • To determine if long-term lithium treatment leads to elevated plasma prolactin compared to controls.

    Main Methods:

    • Longitudinal study of 9 manic-depressive patients before and during lithium treatment.
    • Transversal study of 26 patients on long-term lithium treatment versus 16 controls.
    • Measurement of plasma prolactin levels and assessment of water and sodium balance.

    Main Results:

    • No significant changes in plasma prolactin were observed during lithium treatment.
    • No correlation was found between serum lithium levels and plasma prolactin.
    • Plasma prolactin levels in patients on long-term lithium treatment were not elevated compared to controls.

    Conclusions:

    • Lithium treatment does not appear to cause prolonged elevation of plasma prolactin.
    • Lithium's effect on water and sodium balance is not associated with changes in prolactin levels.
    • Lithium is not among the drugs that induce sustained hyperprolactinemia.

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