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Multinucleated giant cells in thyroid neoplasms. A cytologic, histologic and immunohistochemical study
S O Tabbara1, N Acoury, M K Sidawy
1Department of Pathology, George Washington University Medical Center, Washington, D.C., USA.
Objective:
To evaluate the presence of multinucleated foreign body-type giant cells (MGCs) in papillary carcinoma (PC), follicular variant of papillary carcinoma (FV) and follicular adenomas (FA) and to investigate their origin by immunoperoxidase studies.
Study Design:
The cytologic and histologic material of 10 PCs, 8 FVs, and 11 FAs were evaluated for the presence of MGCs. The immunohistochemical staining pattern of MGCs in paraffin-embedded tissue was studied using cytokeratin, epithelial membrane antigen, thyroglobulin, vimentin, A-1 antichymotrypsin, lysozyme and CD68.
Results:
MGCs were demonstrated in 10/10 PCs, 5/8 FVs and 0/11 FAs. In the immunostained sections, MGCs were negative for epithelial markers and positive for histiocytic markers.
Conclusion:
These results indicate that MGCs are histiocytic and frequently present in PCs and FVs and usually absent from FAs.