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Synthesis and CNS activity of new 1-alkyl-2-aryl-7-hydroxy-5(1H)oxo-imidazo[1,2-a]pyrymidines

D Matosiuk¹, T Tkaczyński, J Stefańczyk

¹Department of Medicines Technology, Faculty of Pharmacy, School of Medicine, Lublin, Poland.

Acta Poloniae Pharmaceutica

|May 1, 1996

Abstract:

Cyclocondensation of 1,5-disubstituted 2-aminoimidazolines with diethyl malonate in the presence of sodium methanolate leading to imidazol[1,2-alpyrimidine-5,7-dion system is presented. Prevailing of 7-hydroxy-5(1H)oxo form between three possible tautomers is discussed based on spectral data. CNS activity of nine compounds is evaluated.

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