Related Experiment Video
Updated: Jul 31, 2026

Three-dimensional Imaging of Nociceptive Intraepidermal Nerve Fibers in Human Skin Biopsies
Published on: April 29, 2013
Paranodal structure in diabetic sensory polyneuropathy
P K Thomas1, N G Beamish, J R Small
1Department of Clinical Neurosciences, Royal Free Hospital School of Medicine, London, UK.
Abstract:
Observations have been made on the structure of the paranodal region at nodes of Ranvier in the sural nerve of patients with diabetic sensory polyneuropathy. The structure of the paranodes was examined with particular attention to the definition and assessment of axoglial dysjunction, which has been claimed to be a characteristic feature of both human and experimental diabetic neuropathy and which has been related to paranodal swelling. In the present series of cases it was not possible to confirm that axoglial dysjunction is a distinctive feature of diabetic polyneuropathy in fibres not undergoing active demyelination or wallerian-type degeneration, neither was excessive paranodal enlargement found.
More Related Videos
10:31Three-dimensional Imaging and Analysis of Mitochondria within Human Intraepidermal Nerve Fibers
Published on: September 29, 2017
09:34Use of In Vivo Single-fiber Recording and Intact Dorsal Root Ganglion with Attached Sciatic Nerve to Examine the Mechanism of Conduction Failure
Published on: August 27, 2019
Related Concept Videos
Local Anesthetics: Differential Sensitivity of Nerve Fibers
Diabetes Insipidus II: Pathophysiology
Type I Diabetes II: Pathophysiology
Type II Diabetes II: Pathophysiology
Diabetic Foot Ulcer
Diabetic Neuropathy